Aldosterone interaction on sodium transport and chloride permeability: influence of epithelial structure
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چکیده
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Aldosterone interaction on sodium transport and chloride permeability: influence of epithelial structure.
The effects of aldosterone on sodium transport and chloride permeability were investigated by electrophysiology in two structurally distinct epithelial used as models for the distal renal tubule: the A6 cell monolayer as compared with the amphibian skin epithelium (ASE). Short-circuit current (Isc) and transepithelial conductance (Gt) were measured in A6 monolayers incubated overnight with(out)...
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There is compelling evidence that active Cl absorption by a variety of epithelia, widely distributed throughout the animal kingdom, is the result of an electrically neutral Na-coupled transport process at the luminal membrane and that the energy for transcellular Cl movement is derived from the Na gradient across that barrier. These co-transport processes are found predominantly in "leaky" or "...
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Despite large changes in salt intake, the mammalian kidney is able to maintain the extracellular sodium concentration and osmolarity within very narrow margins, thereby controlling blood volume and blood pressure. In the aldosterone-sensitive distal nephron (ASDN), aldosterone tightly controls the activities of epithelial sodium channel (ENaC) and Na,K-ATPase, the two limiting factors in establ...
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چکیده ندارد.
15 صفحه اولSodium chloride and aldosterone: harbingers of hypertension-related cardiovascular disease.
Both dietary NaCl consumption and aldosterone have been implicated in the pathogenesis of hypertensionrelated cardiovascular disease. Animal, epidemiological, and clinical studies suggest that a high NaCl intake is associated with myocardial hypertrophy, independent of blood pressure. In vitro, NaCl directly induces hypertrophy in myocardial and vascular smooth muscle cells. Independent of the ...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Biomembranes
سال: 1995
ISSN: 0005-2736
DOI: 10.1016/0005-2736(95)80034-d